The jet belongs to the German airline Germanwings, a subsidiary of Lufthansa.
The plane, flight 4U 9525, had been en route from Barcelona to Dusseldorf with 142 passengers and six crew on board.
French President Francois Hollande said: "The conditions of the accident, which have not yet been clarified, lead us to think there are no survivors."
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President Hollande said the crash was a tragedy, adding that the area was very difficult to access.
Mr Hollande later called German Chancellor Angela Merkel to express his sympathy, the French presidency said.
The plane issued a distress call at 10:47 (09:47 GMT), the French interior ministry said, although details have not been released.
Search-and-rescue teams are headed to the crash site at Meolans-Revels, said regional council head Eric Ciotti.
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